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I have been interested in the immune system metaphor for a while now.The central idea is to draw inspiration from the attractive computational features found in the natural immune system.Like many biologically inspired systems it is adaptive, distributed and autonomous. Artificial immune systems (AIS) can be applied to computer security, data mining, optimisation tasks and other domains. HP are involved in the ARTIST network of excellence and I am personally involved in the EPSRC funded Danger project

AIS and Danger
An intriguing idea, the Danger Theory, is causing waves in the immunological community.It says that the immune system doesn't care about self and non self, but only about danger and non danger. HP are industrial partners on an EPSRC adventure fund programme, a collaboration between immunologists, computer scientists and security experts, where some of these implications will be explored. The main thrust of the project is contained in our ICARIS 2003 paper. I have also co-written a framing paper which summarises the theory and speculates on its implications for AIS research. And my AIS overview for Bristol contains brief notes on the danger theory (among other things).

Gene Libraries
Most AIS implementations are based around a canonical algorithm such as clonotypic learning, which we may think of as individual, lifetime learning. Yet a species also learns. Gene libraries are often thought of as a biological mechanism for generating combinatorial diversity of antibodies. However, they also bias the antibody creation process, so that they can be viewed as a way of guiding the lifetime learning mechanisms. Over time, the gene libraries in a species will evolve to an appropriate bias for the expected environment (based on species memory). Thus, gene libraries are a form of meta-learning which could be useful for AIS. This work is an ongoing project with the University of Bristol and UWE and has resulted in publications at ICARIS 2005 and ICARIS 2006 

AIS and semantic classification
AIRS is a particularly successful AIS based supervised learning algorithm. Using a combination of content and semantic features, we can boost its performance on metadata rich datasets(such as hierarchical document repositories). Our hypothesis is that this machine learning approach will be an ideal match for the task of ontology matching,a task where rigid logic based techniques may fall foul of real world messiness. The vision is described in this paper (accompanying presentation and poster) and formed the basis for Julie Greensmith's MSc thesis. Julie stayed at HP until Christmas 2003 to extend this work.

Julie's work was carried forward by the 2004 BICAS student, Anastasia Krithara from Bristol University. The focus shifted to semantic features, and we used other machine learners in addition to AIRS. The project has been completed, and the findings published in an HP Labs Tech Report

AIS and semantic query
The 'mutate and refine' metaphor used by the AIS is a promising candidate for query expansion on the semantic web. Perhaps this approach might provide a novel and efficient way for users to explore faceted datasets. A Birmingham student, Rana Kashif Ali investigated this using a dataset drawn from SWED. The project was completed in Autumn 2004 and a Tech Report submitted.

Other Projects
AIS and document classification: Using a co-evolutionary immune system metaphor,it is possible to implement an immune based concept learner. This learner has been shown to perform well both on standard machine learning datasets,and on web page classification tasks, where the goal is to assess the relevance of a new web page. The work formed the basis of an MSc thesis by Jamie Twycross,and a short version is available as an HP Labs Tech Report (presented at IIPWM2003).

AIS as a Recommender:My first AIS project used the immune system metaphor for a collaborative filtering problem. I implemented an immune system and applied it to the well known EachMovie recommendation task, achieving pleasing results. The system is described in a CEC 2002 paper, and analysed in a paper presen ted to ICARIS2002. A PowerPoint presentation is also available.

Immune System Resources
I have given a series of presentations about the immune system,the most recent of which (Feb 2006) is a AIS overview given to Bristol University. This is an updated version of my presentation to UCL (Feb 2003). It contains a general overview, details on the document classification project and brief notes about advanced concepts (eg idiotypic effects & danger theory). My CEC2002 presentation contains details concerning AIS as a recommender system.

Please see my resources page for details on code availability, useful links and a list of publications.


Steve Cayzer

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