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A Facile Synthesis of Functionalized Bis(arylethynyl)benzene Derivatives via Sila- Sonogashira Reaction

Zhou, Zhang-Lin; Zhao, Lihua; Zhang, Sean; Vincent, Kent; Lam, Sity; Henze, Dick
HP Laboratories


Keyword(s): Bis(arylethynyl)benzene derivatives, Cross-coupling reaction, Sila-Sonogashira reaction.

Abstract: This paper describes a facile synthesis of a new series of symmetrical bis(arylethynyl)benzene derivatives via a one-pot coupling reaction between trialkylsilyl protected arylalkynyes and aryldihalides bearing both electron-withdrawing (EW) and electron- donating groups (ED) in the presence of PdCl2(PPh3)2 (5%)/CuI/TBAF/TEA/THF (sila-Sonogashira reaction) at room temperature.

13 Pages

Additional Publication Information: To be presented at Synthetic Communications

External Posting Date: November 8, 2010 [Fulltext]. Approved for External Publication
Internal Posting Date: November 8, 2010 [Fulltext]

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